References
Methodology and source domains
Reference
References
Afterburners is built from a small number of recurring evidence domains rather than from isolated supplement claims.
Core evidence areas
- Acetaldehyde toxicology — why acetaldehyde is treated as the
primary damage molecule rather than ethanol itself.
- ALDH2 bottlenecks and saturation — why the second step in
ethanol metabolism becomes rate-limiting.
- Glutathione depletion and redox debt — why alcohol clearance
creates antioxidant deficits that linger into the next day.
- CYP2E1 induction and ROS generation — why backup metabolism is
dirtier than the primary pathway.
- Sleep architecture disruption — why many symptoms emerge in the
rebound window rather than while drinking.
- Cofactor depletion — why thiamine, magnesium, and related
support compounds can matter without being primary interventions.
How the site uses that evidence
The site does not treat every ingredient as equivalent.
- Tier 1 is reserved for direct or non-substitutable interventions.
- Tier 2 supports the primary system.
- Tier 3 and below preserve symptom-specific or long-tail coverage.
The practical way to use the research is:
1. Start with the correct protocol stage. 2. Use the mechanism pages to understand the failure mode. 3. Use ingredient pages for dosing, ranking, and context.
For the live substrate, see the generated ingredient and mechanism libraries: