Same night. Better morning.
Alcohol recovery is not one event. It's a chain of biological windows — before, during the clearance, rebound, morning, and severe — each with its own chemistry and its own ingredient shortlist. Afterburners treats them as five separate problems.
Start with Preflight30 ingredients · 14 mechanisms · 5 stages
Just tell me what to take
The three ingredients that do most of the work, and when to take them.
Quick start → How it worksExplain the system
Five stages, five mechanisms, one architecture. Why timing is the thing most products miss.
The mechanisms → Full depthShow me the research
The biology behind every ingredient and every stage. Acetaldehyde, glutathione, GABA rebound.
Research →Before any supplement matters
Quick start
Five stages
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01 · preflightPreflightTake 1–2 hours before your first drink.
Preflight is the stack you take before your first drink.
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02 · afterburnerAfterburnerTake as soon as you get home from drinking, before sleep.
Afterburner is the stack you take as soon as you walk in the door.
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03 · nightcapNightcapIf you wake up in the middle of the night, or before bed if you know you'll wake up.
Nightcap is the stage most hangover products don't have.
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04 · debriefDebriefTake when you wake up in the morning.
Debrief is the morning-after clean-up.
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05 · maydayMaydayYou're in a severe hangover right now and nothing is working.
Mayday is the full-coverage version of the protocol.
Start from your situation
What the protocol targets
Sleep architecture repair
Protect REM and deep sleep from the clearance window. The largest felt-difference lever.
Hydration & electrolytes
Counter vasopressin suppression and replace sodium and potassium lost to alcohol diuresis.
NAD⁺ restoration
Refill the cofactor pool ethanol crashes — the rate-limiter for ALDH2 and the TCA cycle.
Glutathione restoration
Replenish the antioxidant alcohol depletes fastest; protect ALDH2 from auto-inactivation.
Acetaldehyde clearance
Support ALDH2 (the dominant pathway) during the active clearance window.
Inflammation control
Block the LPS-driven cytokine cascade that prolongs symptoms.
Neurotransmitter rebalance
Dampen glutamate surge and restore calm.
Ingredient reference
Amino acids
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Glycine
Sacrificial amine for acetaldehyde; inhibitory neurotransmitter.
tier 2 -
L-Cysteine
Sulfur substrate for glutathione synthesis; secondary local trap in oral and gastric compartments only.
tier 2 -
NAC (N-Acetyl Cysteine)
Glutathione precursor; acetaminophen safety net.
tier 1
Vitamins & cofactors
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Benfotiamine
Fat-soluble B1; restores the TPP cofactor alcohol depletes.
tier 2 -
Ubiquinol (CoQ10)
Mitochondrial antioxidant; protects ALDH2 from its own byproducts.
tier 2
Minerals
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Magnesium Glycinate
Cofactor and sleep support; commonly depleted by alcohol.
tier 3
Western botanicals
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Silymarin (Milk Thistle)
CYP2E1 suppression; hepatocyte membrane stabilizer.
tier 2 -
Sulforaphane
Nrf2 activator; upregulates ALDH2 before drinking.
tier 1
Traditional Chinese
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Bai Shao
Optional white-peony TCM herb for cramping and tension patterns.
tier 4 -
Ban Xia
Optional TCM anti-nausea herb for queasy morning-after recovery.
tier 4 -
Che Qian Zi
Optional plantain-seed drainage herb for puffy recovery mornings.
tier 4 -
DHM (Dihydromyricetin)
Accelerates alcohol clearance; blunts GABA rebound.
tier 1 -
Fu Ling
Optional poria-based drainage herb in the TCM recovery layer.
tier 4 -
Fu Shen
Optional TCM calming herb for restless rebound after drinking.
tier 4 -
Ge Gen (Kudzu Root)
TCM herb with puerarin; clinical data on alcohol metabolism.
tier 3 -
Gou Qi Zi
Optional goji-based TCM support for dry, wired recovery.
tier 4 -
He Huan Hua
Optional TCM mood-support herb for jagged, irritable recovery.
tier 4 -
Mai Men Dong
Optional TCM fluid-generation herb for dry, depleted recovery.
tier 4 -
Mei Gui Hua
Optional rose-bud TCM support for irritable, constrained recovery.
tier 4 -
Niu Xi
Optional TCM descending-support herb for upward pressure patterns.
tier 4 -
Sang Shen
Optional mulberry-based TCM support for dry, depleted recovery.
tier 4 -
Shi Hu
Optional TCM fluid-support herb for dry, overheated recovery.
tier 4 -
Suan Zao Ren
Optional TCM sleep herb for predictable rebound nights.
tier 4 -
Tu Fu Ling
Optional TCM damp-clearance adjunct for heavy recovery days.
tier 4 -
Wu Wei Zi
Optional schisandra-based liver-support herb in the TCM layer.
tier 4 -
Yan Hu Suo
Optional TCM analgesic herb for residual ache and tension.
tier 4 -
Yin Chen Hao
Optional TCM drainage herb for hot, stagnant morning-after recovery.
tier 4 -
Ze Xie
Optional TCM fluid-shedding herb for swollen, heavy recovery.
tier 4 -
Zhi Huang Qi
Optional TCM repletion herb for flat, depleted recovery mornings.
tier 4 -
Zhu Ling
Optional urinary-drainage herb for puffy, heavy recovery mornings.
tier 4
Core research themes
- What causes a hangover — The underlying biology behind every hangover symptom.
- Acetaldehyde accumulation — The toxic intermediate that drives most of the damage.
- Alcohol and glutathione depletion — Why antioxidant reserves run out during ethanol clearance.
- Hangover inflammation — Cytokine surge, systemic inflammation, and why it lingers.
- Alcohol and sleep disruption — REM suppression, rebound arousal, and the 3am wakeup.
- Alcohol anxiety (next-day jitter) — GABA/glutamate rebound and the morning-after dread.
Research & methodology · Why five stages
Why five stages
Alcohol recovery is not one event. It is a chain of distinct biological windows, each with its own chemistry and its own ingredient shortlist. Preflight is gene induction. Afterburner is acute clearance. Nightcap is rebound management. Debrief is residue cleanup. Mayday is full-coverage recovery when symptoms are severe.
Collapsing them into a single "hangover pill" loses the lead time on sulforaphane, the timing window on DHM, the rebound math on glycine, and the escalation logic on Mayday. Each stage exists because its window cannot be served by any other.
What the system targets
Hangovers are not one mechanism. Acetaldehyde drives the carcinogen-exposure story; for next-morning function, the dominant mechanisms are sleep architecture damage, electrolyte and water loss, NAD⁺ depletion, and gut-derived inflammation. The protocol covers all of them, with the heaviest weight on the levers that produce the largest felt difference per unit effort.
ALDH2 is the dominant enzymatic clearance pathway. The protocol supports it (NAD⁺ via NR; protection via GSH precursors; pre-induction via Nrf2 activators) and addresses the downstream consequences of clearance (electrolyte loss, sleep disruption, inflammation) with separate ingredient layers. Every ingredient on the site is assigned to one or more of these mechanistic roles, and every protocol stage is structured as a tier-ranked stack hitting those roles at the right time.
